Gastric Functions in Gastrin Gene Knock-Out Mice
نویسندگان
چکیده
منابع مشابه
Changes in liver gene expression of Azin1 knock-out mice.
The ornithine decarboxylase antizyme inhibitor (AZI) was discovered as a protein that binds to the regulatory protein antizyme and inhibits the ability of antizyme to interact with the enzyme ornithine decarboxylase (ODC). Several studies showed that the AZI protein is important for cell growth in vitro. However, the function of this gene in vivo remained unclear. In our study, we analyzed the ...
متن کاملTransposon-generated ‘knock-out’ and ‘knock-in’ gene-targeting constructs for use in mice
The conventional technique for targeted mutation of mouse genes entails placing a genomic DNA fragment containing the gene of interest into a vector for fine mapping, followed by cloning of two genomic arms around a selectable neomycin-resistance cassette in a vector containing thymidine kinase [1]; this generally requires 1-2 months of work for each construct. The single 'knock-out' construct ...
متن کاملKnock-out models reveal new aquaporin functions.
Knockout mice have been informative in the discovery of unexpected biological functions of aquaporins. Knockout mice have confirmed the predicted roles of aquaporins in transepithelial fluid transport, as in the urinary concentrating mechanism and glandular fluid secretion. A less obvious, though predictable role of aquaporins is in tissue swelling under stress, as in the brain in stroke, tumor...
متن کاملGastric morphology, gastrin and somatostatin in experimental gastritis in mice.
The purpose of this study was to investigate the morphological changes and endocrine profile in the gastric mucosa of mice with atrophic autoimmune gastritis induced by neonatal thymectomy. The gastritis was produced in neonatal mice (BALB/C( + /?) J of both sexes by thymectomy 3 days after birth. Of the thymectomized mice, 27. 4% had marked reduction of parietal and chief cells as well as infl...
متن کاملBehavioral state instability in orexin knock-out mice.
Narcolepsy is caused by a lack of orexin (hypocretin), but the physiologic process that underlies the sleepiness of narcolepsy is unknown. Using orexin knock-out (KO) mice as a model of narcolepsy, we critically tested the three leading hypotheses: poor circadian control of sleep and wakefulness, inadequate activation of arousal regions, or abnormal sleep homeostasis. Compared with wild-type (W...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Pharmacology and Toxicology
سال: 2002
ISSN: 0901-9928,1600-0773
DOI: 10.1034/j.1600-0773.2002.910614.x